Allicin

Product Item：FA004

White fine powder

Description

Allicin powder

Item	Allicin powder
	15%	25%
Characters	White or yellowish fluidity powder with special odor of garlic
Loss on drying %	≤5%
Chloropropene （per kg ）	≤5g
As	≤3mg/kg
Pb	≤20mg/kg

( Production Standard Q/HBST08-2016)

Main ingredients: Garlic oil, strong bearing capacity, masking odor organic carrier

Storage method: Packing bag is sealed and placed in cool, ventilated and dry place.

Shelf life: 12 months

Net Weight： 1kg/bag ，25bags/ drum 480drums/1X20FCL

Suggestion g/T compound feed

Content 25% (or to be added as appropriate for specific circumstances)

Bio-type	Scent attractant	Promote growth	replace antibiotics
Chickens, eggs, chickens, ducks	50g	80g	150-300g
Piglets, fattening pigs, cows, beef cattle	50g	60g	200-350g
Grass carp, carp, turtle and African crucian carp	80g	120g	350-500g

Product Features:

Allicin is the product of garlic Allium Sativum L. Bulb as raw material, which can be synthesized by chemical industry, and most of allicin used as feed additive is the product of chemical synthesis.

Molecular formula：C₆H₁₀S₂O

Molecular weight：162

Chemical name：DiallylThio-sulfonicacid ester（（CH2=CH-CH2-S(O)-S-CH2-CH=CH2）

CAS No.：539-86-6

[Solubility]: soluble in methanol, ethanol, soluble in water.

[Character]: white powder

Applications：

1. Broad-spectrum antibacterial, bacteriostatic strength. Allicin has obvious curative effect on fish, shrimp, crab, soft shelled turtle caused by infections rotten gills, red spot, enteritis, bleeding and other diseases and complications. The results showed that there was a significant effect on the digestive tract disease, respiratory tract disease, dermatosis and its complication caused by Gram-negative and positive bacteria infection in livestock and poultry. such as dysentery bacillus, typhoid bacillus caused by dysentery, diarrhea, the bacterium caused by bacteria pneumonia, bronchitis, staphylococcus, Pseudomonas aeruginosa caused by purulent dermatosis. The addition of allicin in feed can effectively inhibit the growth of mould, and the effect of mildew is very remarkable. At the same time, livestock, fish and shrimp can drive insects, improve appetite, enhance immune function, non-toxic side effects, no drug residue, no resistance

2. Seasoning for feed, improve the quality of feed. Allicin has a strong, pure natural flavor, which can be used as an alternative to other flavoring agents in the diet. Add 50-150ppm of allicin in feed, can improve the feed of livestock and poultry, fish odor stimulation produced a strong attractant effect, to increase appetite, increase feed intake

3. Enhance immune function, health promotion growth. Allicin has excellent health care function. Adding the right amount of allicin to the feed, the fur light, the physique is strong, the disease resistance strengthens, reduces the feed consumption, enhances the laying hens to produce the egg quantity, may promote the fish and the animal growth, enhances the survival rate.

4. Improve animal quality. Adding a proper amount of allicin to the feed and being ingested by the animal can effectively regulate the formation of the amino acid that stimulates the aroma in the meat, increasing the aroma composition of the animal meat or egg C3h5 (0)-the group produces, thus making the flavor of animal meat or eggs more delicious.

5. Reduce poison drive insect, mildew-proof freshness. Adding allicin to the feed can have the function of clearing plague, detoxification and activating blood circulation stasis, which can significantly reduce the toxicity of harmful substances such as mercury and nitrite in feed. And can effectively dispel mosquitoes, flies, mites, etc., to protect the quality of feed, improve the environment of the stables. Because Allicin has strong inhibition ability to fungi and mould, adding in feed can strengthen or partly replace mildew inhibitor, prevent mildew of feed, prolong feed storage time.

6. Non-toxic, no side effects, no drug residue, no drug resistance. Allicin contains natural bactericidal ingredients, in the animal body in the form of metabolism, different from other antibiotics are non-toxic, no side effects, no drug residue, no drug resistance, can be used continuously, and have anti-virus, improve the fertilization rate of eggs and other unique effects.

7. Against the role of the ball and insect. Allicin has a good control effect on chicken coccidiosis, which can be substituted for the anti-coccidiosis in the non-coccidiosis epidemic area.

Allicin Powder Production Process Description:

Carrier material 1, after 2 weighing, add to the mixer 3; garlic oil by 4 test, after 5 to add to the mixer 3; and the carrier to fully mix, mixed with the product after 6 test, unqualified products according to the provisions of treatment, qualified products by 7, after 8 of quantitative weighing, and then after 9 packaging finished storage. 10 for dedusting Equipment

Mixing 3 uniformity in the production process is the key process

The allicin used in feed industry generally refers to the premix prepared by the synthetic garlic oil adsorption carrier. The main components of the synthetic garlic oil are Diallyl Disulfide(50%--80%), diallyl disulphide (20%--50%), a small amount of mono-vulcanized propylene and four propylene sulfide. The total content of these four kinds of ingredients is generally over 92%.

Sheet 1 The main physical and chemical functions of garlic oil

Items	performance index
Color	Light Yellow Liquid
Odor	A strong smell of garlic
Density	1.050--1.095
Refractive index	1.550--1.580
Dissolving property	Soluble in most nonvolatile oils, partially soluble in ethanol, insoluble in water, glycerin and propylene glycol, etc.
Chemical stability	Strong acids, powerful oxidizing agents and ultraviolet rays can cause deterioration

Synthesis of Alicin

The source of Allicin has two methods, one is the biological extraction method, which is from the natural garlic element distillation from the distillation, the method of low yield, high cost, raw materials seasonal strong; One is the chemical synthesis of allicin and natural extraction of allicin, the main ingredients are consistent, raw materials are easy to obtain, and the concentration of active ingredients is higher than natural extracts, synthetic products in the nature of more stable, bactericidal strength, and the efficacy is faster.

At present, the use of allicin for veterinary and aquatic products, most of the synthetic product. The synthesis of allicin was mainly based on the mixture content of sulfur, propylene and disulfide, and the quality of allicin was indicated, and it was simple and feasible to synthesize the allicin by using sodium sulfide-sodium sulfate as the commonly used in industry. However, due to the need to add a certain amount of formaldehyde and petroleum ether in the process, both pollution environment and petroleum ether need decompression separation, recovery, complex process, high cost and unsatisfactory yield.The company based on the synthetic route to improve its technological process, the use of water phase reaction, not to add formaldehyde and petroleum ether, the raw materials used cheap and easy to have no vacuum distillation process, in the simplification of the process, not only reduce production costs, but also improve the yield, the effect is more ideal.

Application

At present, allicin is widely used in feed industry, and it is generally believed that allicin as a new feed additive has many functions such as sterilization, promoting growth, animal health, seasoning and so on. In order to verify the efficacy of allicin in February 2004-April, we experimented with the effect of garlicin feeding broiler chickens in Zhangqiu chicken farms.

Test results and analysis

Study on the survival rate and feed consumption of broiler chickens see following sheet

Group/ Project

Intial No.

Final No.

Survival rate （%）

Average Initial weight（g）

Average Final weight（g）

Feed consumption（g）

Feed ratio

Trial Group

988

978

98.99

39.6

2287.6

4428.6

1.97

Control Group

988

944

95.55

39.9

2144.3

4293.0

2.04

Conclusions:

1）The addition of allicin in broiler diets can improve the feed intake of broilers, increase the vigor and weight of the chickens, improve the average daily weight by 6.8%, and reduce the ratio of meat to 3.4%. Garlic is rich in natural fragrance, can eliminate the drug in the feed and other substances bring bad taste, improve the palatability of the feed, significantly increase the secretion of animal gastric juice, increase gastrointestinal peristalsis, stimulate animal appetite, thus increasing intake. and allicin can effectively inhibit and kill the digestive tract nitrate and the original bacteria, blocking carcinogenic substance of the synthesis of ammonium nitrate, so as to prevent the digestive tract canceration effect, to ensure the normal physiological function of animal digestive tract.

2）The disulfide and sulfur ether in allicin can enter the cytoplasm through the membrane of the pathogen, oxidize the thiol-containing enzyme to disulfide, inhibit the cell division and destroy the normal metabolism of the bacteria and cancer cells. And for the disease of animals and poultry, the Shigella, pasteurized, typhoid, white staphylococcus, Proteus, Pseudomonas aeruginosa have good inhibition and killing effect, so can replace the other antibiotics in the diet, effectively solve the problem of drug residues in livestock and poultry products, improve the quality of livestock products, protect the environment. In addition, allicin can effectively kill Aspergillus flavus, Aspergillus niger, Aspergillus Niger and other bacteria to prevent the deterioration of feed.

3）adding allicin to the broiler diets enhances the flavor of the chicken and makes the chicken more fresh. According to studies of Thailand, chicken flavor is mainly based on C3H5 (O)-groups, and the sulfur compounds in allicin contain this structure, which can improve the flavor of chicken.

4）To sum up, adding 0.01% allicin in broiler diets can significantly improve the survival rate and daily weight of broilers, and reduce the meat ratio. Improve the feed pay, but also can improve broiler flavor, significantly improve the economic efficiency of broiler. Allicin is an efficient feed additive which is worth popularizing in aquaculture industry.

Other applications

（1） Adding 100-150p allicin to the layer feed can increase the egg production more than 9% and improve the feed utilization rate of more than 9%.

（2）Adding 150ppm allicin to the growing chicken feed can increase the weight gain more than 9%, and the meat ratio drops more than 5%. He Guori (1996) Add 150ppm allicin to the feed, daily gain increased by 8.7%, meat material ratio decreased 4.1%, survival rate 100%, Zheng (1997) added 250ppm allicin in broiler feed, average weight gain 8.7%, consumption decreased 5%, no antibiotic drugs, no chicken and white diarrhea occurred, survival rates 100%.

（3）Adding 200ppm allicin to the feed of grass carp, increasing the weight by 11.8%, improving the feed conversion rate by 12.4%, and increasing the survival rate by 17%.

（4）In fattening pig feed to add 200ppm allicin test, the results show: no diarrhea, enteritis occurrence, appetite enhancement, hair color bright, physique robust, increase the weight of more than 6.2%, feed utilization increased by more than 11.8%, and can prevent Ascaris, hookworm disease.