Description
【Main
Composition】Ceftiofur Hydrochloride
【Physical
appearance】 It is suspension of subparticle,
subparticle sinks when standing and will to be homogeneous milk white
suspension when shaking.
【Pharmacological effect】Pharmacodynamic: This product has broad-spectrum bactericidal effect. It is effective against gram-positive and gram-negative bacteria including β-lactamase-producing bacteria. Sensitive bacteria are mainly Pasteurella multocida, Pasteurella hemolytica, Actinobacillus pleuropneumoniae, Salmonella, E.coli, Streptococcus, Staphylococcus, etc. Some of Pseudomonas aeruginosa and Enterococcus have drug resistance. Its antibacterial activity against Streptococcus stronger than fluoroquinolones. It is commonly used for the treatment of the cattle acute respiratory system infection (e.g. bronchopneumonia caused by Pasteurella), bovine mastitis, pig actinobacillus pleuropneumonia, etc in veterinary clinical.
Pharmacokinetics: Ceftiofur hydrochloride is not suitable for oral
administration which can’t be absorbed. It can be quickly absorbed by
intramuscular/subcutaneous injection and be widely distribution, but can’t pass
through the blood-brain barrier. High drug concentration in blood and tissue
and can last long time. Meanwhile, it can generate active metabolites desfuroyiceftiofur
in the body and further metabolize as inactive product excreted from urine and
feces. This product has long half-life of 3.2, 2.5, 2.8, 14.5, 4.1, 6.8 and 7.5
hours respectively in horse, cattle, sheep, pig, dog, chicken and turkey. This
product can be used in combination with the inhibition of evacuant to improve
blood drug concentration and prolong the half-life.
【Drug
interactions】This product with penicillin and
aminoglycoside combination have synergistic effect.
【Indication】Antibiotic drugs. For the treatment of porcine
bacterial respiratory disease.
【Usage
and dosage】 Intramuscular injection: 5mg/kg of body
weight each time and once a day, 3 consecutive days for pig.
【Adverse reaction】
(1)It has renal toxicity.
(2) It may lead to
gastrointestinal tract flora disorder or double infection.
(3) It may cause
the characteristic of hair removal and itching for cattle.
(4) A few patient
animals may be allergic to ceftiofur.
【Notes】
(1) It should be fully shaken before use
and should not be frozen. It should be used up within 14 days after the first
use.
(2) For
allergic reaction animals which should be treated as injection of epinephrine in
time.
(3) Ceftiofur mainly excreted by renal, for
renal insufficiency animals should be adjust the dosage.
(4)
Keep out of reach of children.
(5)
The staff who have history of
penicillin and cephalosporin drug allergy are prohibited contact with the
goods.
【Withdrawal period】4 days for pig.
【Package】50ml, 100ml or as per your requirements.
【Storage】Stored at cool, dry and dark place with seal.
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